Molecular Cell publishes the Discovery and Characterization of PrimPol, a new Type of Human DNA Polymerase
- PrimPol is the latest polymerase cloned from the human genome. The enzyme displays novel properties with great potential for application in the field of DNA sequencing and amplification.
- The work has been conducted under the direction of Luis Blanco, Professor at CSIC in Madrid and currently Scientific Advisor to SYGNIS AG.
- PrimPol is one of the most innovative products in its field and its thermostable version one of the principal products in SYGNIS late-stage pipeline.
Madrid/Heidelberg, 5 November 2013 – SYGNIS AG (Frankfurt: LIO1; ISIN: DE000A1RFM03; Prime Standard) today announced that Molecular Cell, one of the scientific journals in the Molecular Biology field with the highest impact factor, belonging to the same group that publishes “Cell”, has recently published the paper “PrimPol, an Archaic Primase/Polymerase Operating in Human Cells”
Prof. Luis Blanco, Research Professor at CSIC (Spanish National Research Council, Madrid), X-Pol co-founder and currently Scientific Advisor to SYGNIS AG, is the principal investigator behind the paper, that describes the discovery and characterization of a new type of DNA polymerase, named PrimPol, cloned from the human genome.
PrimPol is one of the most innovative discoveries in the Molecular Biology field and one of the key products in SYGNIS AG’s portfolio. Luis Blanco stated: “I am convinced that this fantastic enzyme will open numerous novel applications in the field of Molecular Biology, some of them we can only hint at this moment given the highly innovative potential of its key features”.
Key features of this enzyme are its duality as a DNA primase and DNA polymerase, and its high tolerance to damaged DNA. The primase function of PrimPol allows it to start reading and copying DNA without the need for providing random primers, as required by all other commercially available polymerases. Using random primers can bias the sequencing and amplification results. The polymerase function of PrimPol displays a high specific activity, being very efficient also when copying DNA with different lesions.
SYGNIS AG is currently developing a new thermostable version of the enzyme that will exploit the features described above, offering a distinctive product with huge potential in the DNA amplification and sequencing field.
The Spanish-German company is proud to point out that the publication of Prof. Blanco’s results in a journal of the impact of Molecular Cell reflects the high scientific quality and novelty of this discovery. This at the same time implies a high likelihood of signing a lucrative licensing agreement with a multinational leader in the field of DNA amplification and next generation sequencing in the coming months.
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